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The resorbable magnesium alloy for scaffolds

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The resorbable magnesium alloy for scaffolds 

With RESOLOY® MeKo offers a bioresorbable magnesium-alloy with extraordinary properties. RESOLOY® is an attractive alternative to polymer scaffolds. In comparison to PLLA, it offers about 3 times higher strength, thinner struts, a higher radial force and is applicable for direct stenting. The degradation time of RESOLOY® is adjusted by coatings. It has a proven biocompatibility, no shelf life and no temperature issues.

RESOLOY® coatings

RESOLOY® Scaffold
  • bioresorbable -> „leaving nothing behind“
  • biocompatibility
  • degradation time adjustable by customized coatings
  • improved break elongation
  • improved ultimate strength
    • reduced scaffold strut thickness
    • small crossing profile
    • higher lumen patency
  • MRI compatibility

Laser Cutting
Stent Tubes

Ø 1,80 mm x 0,160 mm        (Ø 0.071“ x 0.0063“)

Ø 2,20 mm x 0,160 mm        (Ø 0.087“ x 0.0063“)

Ø 3,15 mm x 0,215 mm        (Ø 0.124“ x 0.0085“)

Other tubing dimensions upon request.

Degradation-test lab

MeKo performs in-vitro degradation tests for magnesium scaffolds:

  • simulated blood circulation
  • controlled flow rate, pressure, pulsation and temperature of circulation
  • blood substitute solution for standardized tests: PBS, SBF, ...
  • accelerated in-vitro degradation tests
    •    fast and reproducible evaluation of degradation
    •    monitoring and visualization of degradation process
    •    prediction of in-vivo degradation behaviour
Scaffold strut after 28 days – starting macrophage infiltration

Extensive in vitro and in vivo tests have been performed for a scientific study on the degradation of vascular scaffolds (bioresorbable stents) made from the RESOLOY® magnesium alloy.

The results confirm that the degradation time of RESOLOY® can be adjusted thanks to a double coating of fluoride and polymers. A significantly slower degradation is achieved in vitro compared to the Magmaris®. 

An additional advantage is that RESOLOY® degrades with no residue. The animal tests confirm the in vitro results from the test laboratory and demonstrate that RESOLOY® is highly biocompatible. The results of the published study demonstrate the high degree of safety and efficacy of the alloy.

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